| تعداد نشریات | 22 |
| تعداد شمارهها | 536 |
| تعداد مقالات | 5,580 |
| تعداد مشاهده مقاله | 10,785,240 |
| تعداد دریافت فایل اصل مقاله | 7,154,347 |
A Comprehensive Review of Microneedling and Facial Skincare Strategies in Anti-Aging Dermatology | ||
| Avicenna Veterinary Research | ||
| مقاله 2، دوره 2، شماره 1، خرداد 2026، صفحه 11-30 اصل مقاله (3.37 M) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22084/avr.2025.31508.1017 | ||
| نویسندگان | ||
| arash younesi1؛ Hassan Morovvati* 2؛ Hossein Najaf Zadeh Varzi3 | ||
| 1Ph.D Candidate, Department of Basic Science, Faculty of Veterinary Medicine University of Tehran. Tehran, Iran | ||
| 2Professor, Department of Basic Science, Faculty of Veterinary Medicine University of Tehran. Tehran, Iran | ||
| 3Professor, Department of pharmacology, Faculty of Medical Science, Babol, Iran | ||
| چکیده | ||
| These days, there are different techniques for skin rejuvenation. One of them is microneedling, which can improve skin health with minimal side effects and good results. Microneedling is an effective skincare method for facial rejuvenation. It is a good source of growth factors, cytokines, and other biologically active substances that can enhance rejuvenation and wound healing processes. During the microneedling method, all these substances are obtained from the patient's blood without any pain and have the advantage of reducing the immune response, making the procedure safer and better tolerated, with minimal side effects and lower cost. Therefore, it is a useful approach for skin anti-aging. It is currently being used extensively for facial rejuvenation. In this process, using a combination of microneedling, mesotherapy techniques, and facial skincare for treating acne scars, melasma, and facial scars is more powerful. So, in this article, the microneedling method and its remarkable effects on skin anti-aging and reducing skin problems will be studied. | ||
| کلیدواژهها | ||
| Skin؛ Rejuvenation؛ Microneedling؛ Skincare؛ Melasma | ||
| مراجع | ||
|
References [1] Buzalaf MAR, Levy FM. Autologous platelet con- centrates for facial rejuvenation. Journal of Ap- plied Oral Science. 2022;30:e20220020. [2] Orentreich DS, Orentreich N. Subcutaneous in- cisionless (subcision) surgery for the correction of depressed scars and wrinkles. Dermatologic Surgery. 1995;21(6):543-9. [3] Camirand A, Doucet J. Needle dermabrasion. Aes- thetic plastic surgery. 1997;21:48-51. [4] Amit B. MICRO NEEDLING-FACTS AND FIC- TIONS. Asian Journal of Medical Sciences. 2013;4(3). [5] Fernandes D. Minimally invasive percutaneous collagen induction. Oral and Maxillofacial Surgery Clinics. 2005;17(1):51-63. [6] Yaar M, Eller MS, Gilchrest BA, editors. Fifty years of skin aging. Journal of Investigative Der- matology Symposium Proceedings; 2002: Else- vier. [7] Gilchrest BA. Skin aging and photoaging: an overview. Journal of the American Academy of Dermatology. 1989;21(3):610-3. [8] Yaar M, Gilchrest BA. Skin aging: postulated mechanisms and consequent changes in struc- ture and function. Clinics in geriatric medicine. 2001;17(4):617-30. [9] Krutmann J, Schikowski T, Morita A, Berneb- urg M. Environmentally-induced (extrinsic) skin aging: Exposomal factors and underlying mech- anisms. Journal of Investigative Dermatology. 2021;141(4):1096-103. [10] Wadstein J, Alvarez IS, Lpez LB. Managing Skin Ageing as a Modi able DisorderThe Clinical Ap- plication of Nourella Dual Approach Compris- ing a Nano-Encapsulated Retinoid, Retilex-A and a Skin Proteoglycan Replacement Therapy, Ver- cilex. Cosmetics. 2022;9(2):31. [11] Zhang S, Duan E. Fighting against skin aging: the way from bench to bedside. Cell transplantation. 2018;27(5):729-38. [12] Kammeyer A, Luiten R. Oxidation events and skin aging. Ageing research reviews. 2015;21:16-29. [13] ElDomyati M, Moftah NH, Nasif GA, Ameen SW, Ibrahim MR, Ragaie MH. Facial rejuvenation us- ing stem cell conditioned media combined with skin needling: a splitface comparative study. Jour- nal of Cosmetic Dermatology. 2020;19(9):2404-10. [14] Cassiano DP, Esposito ACC, Hassun KM, de Andrade Lima EV, Bagatin E, Miot HA. Early clinical and histological changes induced by mi- croneedling in facial melasma: a pilot study. In- dian journal of dermatology, venereology and lep- rology. 2019;85:638. [15] Zarei F, Abbaszadeh A. Application of cell ther- apy for anti-aging facial skin. Current stem cell research & therapy. 2019;14(3):244-8. [16] Suh A, Pham A, Cress MJ, Pincelli T, TerKonda SP, Bruce AJ, et al. Adipose-derived cellular and cell-derived regenerative therapies in dermatology and aesthetic rejuvenation. Ageing research re- views. 2019;54:100933. [17] Kim S-N, Lee C-J, Nam J, Choi B, Chung E, Song SU. The effects of human bone marrow-derived mesenchymal stem cell conditioned media pro- duced with fetal bovine serum or human platelet lysate on skin rejuvenation characteristics. Inter- national Journal of Stem Cells. 2021;14(1):94. [18] Li L, Ngo HT, Hwang E, Wei X, Liu Y, Liu J, Yi T-H. Conditioned medium from human adipose- derived mesenchymal stem cell culture prevents UVB-induced skin aging in human keratinocytes and dermal broblasts. International journal of molecular sciences. 2019;21(1):49. [19] Ahn S, Kim S, Lee H, Moon S, Chang I. Cor- relation between a Cutometer and quantitative evaluation using Moire topography in agerelated skin elasticity. Skin Research and Technology. 2007;13(3):280-4. [20] Akhtar N, Zaman SU, Khan BA, Amir MN, Ebrahimzadeh MA. Calendula extract: effects on mechanical parameters of human skin. Acta Pol Pharm. 2011;68(5):693-701. Avicenna Veterinary Research/ Vol. 2, No. 1, Spring 2026 25 [21] Cho S-W, Moon S-H, Lee S-H, Kang S-W, Kim J, Lim JM, et al. Improvement of postna- tal neovascularization by human embryonic stem cellderived endothelial-like cell transplantation in a mouse model of hindlimb ischemia. Circulation. 2007;116(21):2409-19. [22] Lee MJ, Kim J, Lee KI, Shin JM, Chae JI, Chung HM. Enhancement of wound healing by secre- tory factors of endothelial precursor cells derived from human embryonic stem cells. Cytotherapy. 2011;13(2):165-78. [23] Fitzpatrick RE, Rostan EF. Reversal of pho- todamage with topical growth factors: a pilot study. Journal of Cosmetic and Laser Therapy. 2003;5(1):25-34. [24] Kim W-S, Park S-H, Ahn S-J, Kim H-K, Park J-S, Lee G-Y, et al. Whitening effect of adipose-derived stem cells: a critical role of TGF- 1. Biological and Pharmaceutical Bulletin. 2008;31(4):606-10. [25] Velugotla K, Ritambhara AS, Gupta PK. A single arm, monocentric, prospective, open label study to evaluate anti-ageing efficacy of human growth factors and cytokines containing cosmetic skin serum in Indian female population. 2017. [26] Kim W-S, Park B-S, Park S-H, Kim H-K, Sung J-H. Antiwrinkle effect of adipose-derived stem cell: activation of dermal broblast by secre- tory factors. Journal of dermatological science. 2009;53(2):96-102. [27] PARK BS, Jang KA, SUNG JH, PARK JS, Kwon YH, Kim KJ, KIM WS. Adiposederived stem cells and their secretory factors as a promis- ing therapy for skin aging. Dermatologic Surgery. 2008;34(10):1323-6. [28] Bos JD, Meinardi MM. The 500 Dalton rule for the skin penetration of chemical compounds and drugs. Experimental Dermatology: Viewpoint. 2000;9(3):165-9. [29] Jakasa I, Verberk MM, Esposito M, Bos JD, Kezic S. Altered penetration of polyethylene gly- cols into uninvolved skin of atopic dermatitis patients. Journal of Investigative Dermatology. 2007;127(1):129-34. [30] Fabi S, Sundaram H. The potential of topi- cal and injectable growth factors and cytokines for skin rejuvenation. Facial Plastic Surgery. 2014;30(02):157-71. [31] Boismal F, Serror K, Dobos G, Zuelgaray E, Ben- sussan A, Michel L. Skin aging: Pathophysiol- ogy and innovative therapies. Medecine Sciences: M/S. 2020;36(12):1163-72. [32] Choy YB, Prausnitz MR. The rule of ve for non- oral routes of drug delivery: ophthalmic, inhala- tion and transdermal. Pharmaceutical research. 2011;28:943-8. [33] Yang D, Chen M, Sun Y, Jin Y, Lu C, Pan X, et al. Microneedle-mediated transdermal drug deliv- ery for treating diverse skin diseases. Acta Bioma- terialia. 2021;121:119-33. [34] Soliman YS, Horowitz R, Hashim PW, Nia JK, Farberg AS, Goldenberg G. Update on acne scar treatment. Cutis. 2018;102(1):21. [35] Gupta J, Gill HS, Andrews SN, Prausnitz MR. Ki- netics of skin resealing after insertion of micronee- dles in human subjects. Journal of controlled re- lease. 2011;154(2):148-55. [36] Arora S, Gupta PB. Automated microneedling device-a new tool in dermatologist's kit-a review. Journal of Pakistan Association of Dermatolo- gists. 2012;22(4). [37] Fernandes D, Signorini M. Combating photoaging with percutaneous collagen induction. Clinics in dermatology. 2008;26(2):192-9. [38] Hou A, Cohen B, Haimovic A, Elbuluk N. Mi- croneedling: a comprehensive review. Dermato- logic Surgery. 2017;43(3):321-39. [39] Cohen BE, Elbuluk N. Microneedling in skin of color: a review of uses and efficacy. Jour- nal of the American Academy of Dermatology. 2016;74(2):348-55. [40] Chandrashekar BS, Sriram R, Mysore R, Bhaskar S, Shetty A. Evaluation of microneedling frac- tional radiofrequency device for treatment of acne scars. Journal of cutaneous and aesthetic surgery. 2014;7(2):93-7. [41] Dave R, Shinde S, Kalayil N, Budar A. En- gineering microscopic delivery systems: a re- view of dissolving microneedle design, fabrication, and function. Micro and Nano Systems Letters. 2024;12(1):14. [42] Liebl H, Kloth LC. Skin cell proliferation stim- ulated by microneedles. Journal of the American College of ClinicalWound Specialists. 2012;4(1):2- 6. [43] Serrano G, Almudver P, Serrano JM, Cortijo J, Faus C, Reyes M, et al. Microneedling dilates the follicular infundibulum and increases transfollic- ular absorption of liposomal sepia melanin. Clin- ical, Cosmetic and Investigational Dermatology. 2015:313-8. A Comprehensive Review of Microneedling and Facial ...: 11{30 26 [44] Nair PA, Arora TH. Microneedling using der- maroller: A means of collagen induction therapy. GMJ. 2014;69(1):24-7. [45] Freinkel RK, Woodley DT. The biology of the skin: CRC Press; 2001. [46] Fabbrocini G, Fardella N, Monfrecola A, Proietti I, Innocenzi D. Acne scarring treatment using skin needling. Clinical and experimental dermatology. 2009;34(8):874-9. [47] Aust MC, Fernandes D, Kolokythas P, Kaplan HM, Vogt PM. Percutaneous collagen induction therapy: an alternative treatment for scars, wrin- kles, and skin laxity. Plastic and reconstructive surgery. 2008;121(4):1421-9. [48] Majid I, Sheikh G, September P. Microneedling and its applications in dermatology. Prime Int J Aesthetic Anti-Ageing Med Healthcare. 2014;4(7):44-9. [49] Kloth LC. Electrical stimulation for wound heal- ing: a review of evidence from in vitro stud- ies, animal experiments, and clinical trials. The international journal of lower extremity wounds. 2005;4(1):23-44. [50] Aust MC, Reimers K, Repenning C, Stahl F, Jahn S, Guggenheim M, et al. Percutaneous col- lagen induction: minimally invasive skin reju- venation without risk of hyperpigmentationfact or ction? Plastic and reconstructive surgery. 2008;122(5):1553-63. [51] Bonati LM, Epstein GK, Strugar TL. Mi- croneedling in all skin types: a review. Journal of Drugs in Dermatology: JDD. 2017;16(4):308-13. [52] Pamela RD. Topical growth factors for the treat- ment of facial photoaging: a clinical experience of eight cases. The Journal of clinical and aesthetic dermatology. 2018;11(12):28. [53] Lee HJ, Lee EG, Kang S, Sung J-H, Chung H-M, Kim DH. Efficacy of microneedling plus human stem cell conditioned medium for skin rejuvena- tion: a randomized, controlled, blinded split-face study. Annals of dermatology. 2014;26(5):584. [54] Schaefer H, Lademann J. The role of follicular penetration. Skin Pharmacology and Physiology. 2001;14(Suppl. 1):23-7. [55] Sun X, Jia X, Huang L. Microneedling Therapy for Striae Distensae: Systematic Review and Meta- Analysis. Aesthetic Plastic Surgery. 2024:1-12. [56] Iriarte C, Awosika O, Rengifo-Pardo M, Ehrlich A. Review of applications of microneedling in derma- tology. Clinical, cosmetic and investigational der- matology. 2017:289-98. [57] Wu SZ, Muddasani S, Alam M. A systematic re- view of the efficacy and safety of microneedling in the treatment of melasma. Dermatologic Surgery. 2020;46(12):1636-41. [58] Kim JK, Roh MR, PARK Gh, Kim YJ, Jeon IK, Chang SE. Fractionated microneedle radiofre- quency for the treatment of periorbital wrinkles. The Journal of dermatology. 2013;40(3):172-6. [59] Juhasz ML, Cohen JL. Microneedling for the treatment of scars: an update for clinicians. Clin- ical, cosmetic and investigational dermatology. 2020:997-1003. [60] Huertas ACM, Schmelzer CE, Hoehenwarter W, Heyroth F, Heinz A. Molecular-level insights into aging processes of skin elastin. Biochimie. 2016;128:163-73. [61] Aldag C, Nogueira Teixeira D, Leventhal PS. Skin rejuvenation using cosmetic products containing growth factors, cytokines, and matrikines: a re- view of the literature. Clinical, Cosmetic and In- vestigational Dermatology. 2016:411-9. [62] Bergman D, Luke J. Azelaic acid. Journal of the Dermatology Nurses' Association. 2017;9(3):157- 60. [63] Nautiyal A, Wairkar S. Management of hyper- pigmentation: Current treatments and emerg- ing therapies. Pigment cell & melanoma research. 2021;34(6):1000-14. [64] Mazurek K, Pierzchaa E. Comparison of ef- cacy of products containing azelaic acid in melasma treatment. Journal of cosmetic derma- tology. 2016;15(3):269-82. [65] Hwang S-W, Oh D-J, Lee D, Kim J-W, Park S-W. Clinical efficacy of 25% L-ascorbic acid (C'ensil) in the treatment of melasma. Journal of cutaneous medicine and surgery. 2009;13(2):74-81. [66] Oresajo C, Stephens T, Hino PD, Law RM, Yatskayer M, Foltis P, et al. Protective effects of a topical antioxidant mixture containing vitamin C, Ferulic acid, and Phloretin against ultravio- letinduced Photodamage in human skin. Journal of cosmetic dermatology. 2008;7(4):290-7. [67] Murray JC, Burch JA, Streilein RD, Iannacchione MA, Hall RP, Pinnell SR. A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin Avicenna Veterinary Research/ Vol. 2, No. 1, Spring 2026 27 against damage caused by ultraviolet irradiation. Journal of the American Academy of Dermatol- ogy. 2008;59(3):418-25. [68] Kameyama K, Sakai C, Kondoh S, Yonemoto K, Nishiyama S, Tagawa M, et al. Inhibitory ef- fect of magnesium L-ascorbyl-2-phosphate (VC- PMG) on melanogenesis in vitro and in vivo. Jour- nal of the American Academy of Dermatology. 1996;34(1):29-33. [69] AlgiertZielinska B, Mucha P, Rotsztejn H. Ef- fects of lactobionic acid peel, aluminum oxide crystal microdermabrasion, and both procedures on skin hydration, elasticity, and transepider- mal water loss. Journal of cosmetic dermatology. 2019;18(5):1463-74. [70] Matthews-Brzozowska T, Lacka M, Bernacka M, Lichaj M. Mesotherapya method of facial skin re- juvenation from an interdisciplinary perspective on improving facial aesthetics. Journal of Medical Science. 2017;86(4):308-12. [71] Jung GS, Eom JR, Jeon HJ, Chu SG, Oh E, Lee JW. Facial rejuvenating effects of mesotherapy us- ing a new polycomponent formulation. Medical Lasers; Engineering, Basic Research, and Clinical Application. 2018;7(2):69-73. [72] Tedeschi A, Lacarrubba F, Micali G. Mesotherapy with an intradermal hyaluronic acid formulation for skin rejuvenation: an intrapatient, placebo- controlled, long-term trial using high-frequency ultrasound. Aesthetic plastic surgery. 2015;39:129- 33. [73] Wojcik A, Kubiak M, Rotsztejn H. In uence of azelaic and mandelic acid peels on sebum secre- tion in ageing women. Advances in Dermatol- ogy and Allergology/Postepy Dermatologii i Aler- gologii. 2013;30(3):140-5. [74] Yadav S, Dogra S. A Cutaneous Reaction to Microneedling for Postacne Scarring Caused by Nickel Hypersensitivity. Aesthet Surg J. 2016;36(4):Np168-70. [75] Garg S, Baveja S. Combination therapy in the management of atrophic acne scars. J Cutan Aes- thet Surg. 2014;7(1):18-23. [76] Majid I. Microneedling therapy in atrophic facial scars: an objective assessment. J Cutan Aesthet Surg. 2009;2(1):26-30. [77] Sharad J. Combination of microneedling and gly- colic acid peels for the treatment of acne scars in dark skin. J Cosmet Dermatol. 2011;10(4):317-23. [78] Leheta T, El Tawdy A, Abdel Hay R, Farid S. Percutaneous collagen induction versus full- concentration trichloroacetic acid in the treat- ment of atrophic acne scars. Dermatol Surg. 2011;37(2):207-16. [79] Khater MH, Khattab FM, Abdelhaleem MR. Treatment of striae distensae with needling ther- apy versus CO2 fractional laser. J Cosmet Laser Ther. 2016;18(2):75-9. [80] Pahwa M, Pahwa P, Zaheer A. "Tram track effect" after treatment of acne scars using a microneedling device. Dermatol Surg. 2012;38(7 Pt 1):1107-8. [81] Park KY, Kim HK, Kim SE, Kim BJ, Kim MN. Treatment of striae distensae using needling therapy: a pilot study. Dermatol Surg. 2012;38(11):1823-8. [82] Fabbrocini G, De Vita V, Monfrecola A, De Padova MP, Brazzini B, Teixeira F, Chu A. Percu- taneous collagen induction: an effective and safe treatment for post-acne scarring in different skin phototypes. J Dermatolog Treat. 2014;25(2):147- 52. [83] Dogra S, Yadav S, Sarangal R. Microneedling for acne scars in Asian skin type: an effective low cost treatment modality. J Cosmet Dermatol. 2014;13(3):180-7. [84] Sharad J. Combination of microneedling and gly- colic acid peels for the treatment of acne scars in dark skin. Journal of cosmetic dermatology. 2011;10(4):317-23. [85] Asif M, Kanodia S, Singh K. Combined autologous platelet-rich plasma with microneedling verses mi- croneedling with distilled water in the treatment of atrophic acne scars: a concurrent split-face study. J Cosmet Dermatol. 2016;15(4):434-43. [86] Cachafeiro T, Escobar G, Maldonado G, Ces- tari T, Corleta O. Comparison of Nonablative Fractional Erbium Laser 1,340 nm and Mi- croneedling for the Treatment of Atrophic Acne Scars: A Randomized Clinical Trial. Dermatol Surg. 2016;42(2):232-41. [87] Seo KY, Kim DH, Lee SE, Yoon MS, Lee HJ. Skin rejuvenation by microneedle fractional ra- diofrequency and a human stem cell conditioned medium in Asian skin: a randomized controlled in- vestigator blinded split-face study. J Cosmet Laser Ther. 2013;15(1):25-33. [88] Calderhead RG, Goo BL, Lauro F, Gursoy D, Savant SS, Wronski A. The clinical efficacy and safety of microneedling fractional radiofrequency A Comprehensive Review of Microneedling and Facial ...: 11{30 28 in the treatment of facial wrinkles: A multicen- ter study with the In ni System in 499 patients. White paper, Lutronic Corp, Goyang, South Ko- rea. 2013. [89] Uitto J. The role of elastin and collagen in cuta- neous aging: intrinsic aging versus photoexposure. Journal of drugs in dermatology: JDD. 2008;7(2 Suppl):s12-6. [90] Arnoczky SP, Aksan A. Thermal modi cation of connective tissues: basic science considera- tions and clinical implications. JAAOS-Journal of the American Academy of Orthopaedic Surgeons. 2000;8(5):305-13. [91] Dierickx CC. The role of deep heating for non- invasive skin rejuvenation. Lasers in Surgery and Medicine: The Official Journal of the Amer- ican Society for Laser Medicine and Surgery. 2006;38(9):799-807. [92] Hantash BM, Ubeid AA, Chang H, Ka R, Renton B. Bipolar fractional radiofrequency treatment in- duces neoelastogenesis and neocollagenesis. Lasers in Surgery and Medicine: The Official Journal of the American Society for Laser Medicine and Surgery. 2009;41(1):1-9. [93] Hantash BM, Renton B, Berkowitz RL, Stridde BC, Newman J. Pilot clinical study of a novel minimally invasive bipolar microneedle radiofre- quency device. Lasers in Surgery and Medicine: The Official Journal of the American Society for Laser Medicine and Surgery. 2009;41(2):87-95. [94] Hruza G, Taub AF, Collier SL, Mulholland SR. Skin rejuvenation and wrinkle reduction using a fractional radiofrequency system. Journal of Drugs in Dermatology: JDD. 2009;8(3):259-65. [95] Seo KY, Yoon MS, Kim DH, Lee HJ. Skin reju- venation by microneedle fractional radiofrequency treatment in Asian skin; clinical and histolog- ical analysis. Lasers in surgery and medicine. 2012;44(8):631-6. [96] Lee HS, Lee DH,Won CH, Chang HW, Kwon HH, Kim KH, Chung JH. Fractional rejuvenation us- ing a novel bipolar radiofrequency system in Asian skin. Dermatologic surgery. 2011;37(11):1611-9. [97] Gold M, Taylor M, Rothaus K, Tanaka Y. Non- insulated smooth motion, microneedles RF frac- tional treatment for wrinkle reduction and lifting of the lower face: International study. Lasers in surgery and medicine. 2016;48(8):727-33. [98] Tanaka Y. Longterm threedimensional volumet- ric assessment of skin tightening using a sharply tapered noninsulated microneedle radiofrequency applicator with novel fractionated pulse mode in Asians. Lasers in surgery and medicine. 2015;47(8):626-33. [99] Alexiades-Armenakas M, Rosenberg D, Renton B, Dover J, Arndt K. Blinded, randomized, quan- titative grading comparison of minimally inva- sive, fractional radiofrequency and surgical face- lift to treat skin laxity. Archives of dermatology. 2010;146(4):396-405. [100] Shapiro S. VoluDerm microneedle technology for treating skin laxity and wrinklesinitial clinical ex- perience. Jacobs J Exp Dermatol. 2015;1(2):1-7. [101] Cha J, Falanga V. Stem cells in cutaneous wound healing. Clinics in dermatology. 2007;25(1):73-8. [102] Kim W-S, Park B-S, Sung J-H. Protective role of adipose-derived stem cells and their soluble fac- tors in photoaging. Archives of dermatological re- search. 2009;301:329-36. [103] Makrantonaki E, Zouboulis C. Molecular mecha- nisms of skin aging: state of the art. Annals of the New York Academy of Sciences. 2007;1119(1):40- 50. [104] Mukherjee PK, Maity N, Nema NK, Sarkar BK. Bioactive compounds from natural resources against skin aging. Phytomedicine. 2011;19(1):64- 73. [105] Sproul EP, Argraves WS. A cytokine axis reg- ulates elastin formation and degradation. Matrix Biology. 2013;32(2):86-94. [106] Uitto J, Kouba D. Cytokine modulation of ex- tracellular matrix gene expression: relevance to brotic skin diseases. Journal of dermatological science. 2000;24:S60-S9. [107] Verrecchia F, Mauviel A. Transforming growth factor- and brosis. World journal of gastroen- terology: WJG. 2007;13(22):3056. [108] Tammi R, Pasonen-Seppnen S, Kolehmainen E, Tammi M. Hyaluronan synthase induction and hyaluronan accumulation in mouse epidermis fol- lowing skin injury. Journal of Investigative Der- matology. 2005;124(5):898-905. [109] Kay-Hendrik B, Antigona A, Nicole W, Matthias A. Medical Needling: Effect on Moisture and Transepidermal Water Loss of Mature Hyper- trophic Burn Scars. Cureus. 2018. [110] Kim M, Yang H, Kim H, Jung H, Jung H. Novel cosmetic patches for wrinkle improvement: Retinyl retinoateand ascorbic acidloaded dissolv- ing microneedles. International journal of cosmetic science. 2014;36(3):207-12. Avicenna Veterinary Research/ Vol. 2, No. 1, Spring 2026 29 [111] Bao P, Kodra A, Tomic-Canic M, Golinko MS, Ehrlich HP, Brem H. The role of vascular endothe- lial growth factor in wound healing. Journal of Surgical Research. 2009;153(2):347-58. [112] Faler BJ, Macsata RA, Plummer D, Mishra L, Sidawy AN. Transforming growth factor- and wound healing. Perspectives in vascular surgery and endovascular therapy. 2006;18(1):55-62. [113] Bandyopadhyay B, Fan J, Guan S, Li Y, Chen M, Woodley DT, Li W. A traffic control role for TGF3: orchestrating dermal and epidermal cell motility during wound healing. The Journal of cell biology. 2006;172(7):1093-105. [114] Ferguson MW, O'Kane S. Scarfree healing: from embryonic mechanisms to adult therapeutic inter- vention. Philosophical Transactions of the Royal Society of London Series B: Biological Sciences. 2004;359(1445):839-50. [115] Tan MG, Jo CE, Chapas A, Khetarpal S, Dover JS. Radiofrequency microneedling: a comprehen- sive and critical review. Dermatologic Surgery. 2021;47(6):755-61. [116] Dayan E, Chia C, Burns AJ, Theodorou S. Ad- justable depth fractional radiofrequency combined with bipolar radiofrequency: a minimally invasive combination treatment for skin laxity. Aesthetic surgery journal. 2019;39(Suppl 3):S112. [117] Alessa D, Bloom JD. Microneedling options for skin rejuvenation, including non-temperature- controlled fractional microneedle radiofrequency treatments. Facial plastic surgery clinics of North America. 2020;28(1):1-7. | ||
|
آمار تعداد مشاهده مقاله: 215 تعداد دریافت فایل اصل مقاله: 22 |
||