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Baseri Azghandi, Mohammad, Nafisi, Saeed, Hallaj-Salahipour, Mahsa. (1404). Evaluation of Hemoglobin and Oxyhemoglobin Dynamics Following Trifluralin Administration in Wistar Rats. پژوهش های زبان شناسی تطبیقی, (), -. doi: 10.22084/avr.2025.31480.1015
Mohammad Baseri Azghandi; Saeed Nafisi Nafisi; Mahsa Hallaj-Salahipour. "Evaluation of Hemoglobin and Oxyhemoglobin Dynamics Following Trifluralin Administration in Wistar Rats". پژوهش های زبان شناسی تطبیقی, , , 1404, -. doi: 10.22084/avr.2025.31480.1015
Baseri Azghandi, Mohammad, Nafisi, Saeed, Hallaj-Salahipour, Mahsa. (1404). 'Evaluation of Hemoglobin and Oxyhemoglobin Dynamics Following Trifluralin Administration in Wistar Rats', پژوهش های زبان شناسی تطبیقی, (), pp. -. doi: 10.22084/avr.2025.31480.1015
Baseri Azghandi, Mohammad, Nafisi, Saeed, Hallaj-Salahipour, Mahsa. Evaluation of Hemoglobin and Oxyhemoglobin Dynamics Following Trifluralin Administration in Wistar Rats. پژوهش های زبان شناسی تطبیقی, 1404; (): -. doi: 10.22084/avr.2025.31480.1015

Evaluation of Hemoglobin and Oxyhemoglobin Dynamics Following Trifluralin Administration in Wistar Rats

Avicenna Veterinary Research
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 20 آبان 1404
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22084/avr.2025.31480.1015
نویسندگان
Mohammad Baseri Azghandi1؛ Saeed Nafisi Nafisi2؛ Mahsa Hallaj-Salahipour* 3
1DVM, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
2Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
3Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
چکیده
Background: Trifluralin is a widely used dinitroaniline herbicide known for its soil persistence and microtubule-disrupting activity. While its phytotoxic and genotoxic effects are well documented, its acute impact on hematological parameters—particularly oxygen transport biomarkers—remains poorly understood in veterinary models. This study aimed to evaluate the dose- and time-dependent effects of trifluralin on total hemoglobin and oxyhemoglobin concentrations in female Wistar rats following intraperitoneal administration .

Material & Methods: Rats were administered trifluralin at doses of 250, 500, and 750 mg/kg (24% concentration), and blood samples were collected at 30 and 60 minutes post-injection. Spectrophotometric analysis was used to quantify total hemoglobin and oxyhemoglobin levels. Statistical comparisons between control and treated groups were performed.

Results: Trifluralin administration led to dose- and time-dependent elevations in hemoglobin parameters. Significant increases in total hemoglobin were observed at 250 and 500 mg/kg within 30 minutes, with the highest oxyhemoglobin level recorded at 750 mg/kg. At 60 minutes, hemoglobin values in lower dose groups showed partial decline, while oxyhemoglobin remained elevated in the high-dose group..

Conclusion: These findings suggest that trifluralin may induce transient hematological stimulation and modulate oxygen transport capacity, depending on dose and exposure duration. Further investigation is needed to clarify the underlying mechanisms and systemic implications.
کلیدواژه‌ها
Trifluralin؛ Hematotoxicity؛ Oxyhemoglobin؛ Wistar rats؛ Herbicide toxicity
آمار
تعداد مشاهده مقاله: 14


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