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Evaluation of Hemoglobin and Oxyhemoglobin Dynamics Following Triuralin Administration in Wistar Rats | ||
| Avicenna Veterinary Research | ||
| مقاله 1، دوره 1، شماره 4، اسفند 2025، صفحه 1-6 اصل مقاله (1.46 M) | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22084/avr.2025.31480.1015 | ||
| نویسندگان | ||
| Mohammad Baseri Azghandi1؛ Saeed Nafisi* 2؛ Mahsa Hallaj-Salahipour2 | ||
| 1Faculty of Veterinary Medicine, Urmia University, Urmia, Iran | ||
| 2Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran | ||
| چکیده | ||
| Tri uralin is a widely used dinitroaniline herbicide known for its soil persistence and microtubule-disrupting activity. While its phytotoxic and genotoxic effects are well documented, its acute impact on hematological parameters-particularly oxygen transport biomarkers-remains poorly understood in veterinary models. This study aimed to evaluate the dose and time-dependent effects of tri uralin on total hemoglobin and oxyhemoglobin concentrations in female Wistar rats following intraperitoneal administration. Rats were administered tri uralin at doses of 250, 500, and 750 mg/kg (24% concentration), and blood samples were collected at 30- and 60-minutes post-injection. Spectrophotometric analysis was used to quantify total hemoglobin and oxyhemoglobin levels. Statistical comparisons between control and treated groups were performed. Tri uralin administration led to dose- and time-dependent elevations in hemoglobin parameters. Signicant increases in total hemoglobin were observed at 250 and 500 mg/kg within 30 minutes, with the highest oxyhemoglobin level recorded at 750 mg/kg. At 60 minutes, hemoglobin values in lower dose groups showed partial decline, while oxyhemoglobin remained elevated in the high-dose group. These ndings suggest that tri uralin may induce transient hematological stimulation and modulate oxygen transport capacity, depending on dose and exposure duration. Further investigation is needed to clarify the underlying mechanisms and systemic implications. | ||
| کلیدواژهها | ||
| Triuralin؛ Hematotoxicity؛ Oxyhemoglobin؛ Wistar rats؛ Hypoxia؛ Herbicide toxicity؛ Spectrophotometry | ||
| مراجع | ||
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