دانشگاه بوعلی سینا

  اخبار و اعلانات

 آمار

تعداد نشریات22
تعداد شماره‌ها495
تعداد مقالات5,168
تعداد مشاهده مقاله9,586,486
تعداد دریافت فایل اصل مقاله6,314,528
Zolhavarieh, Seyed Masoud, Yousefi, Mojtaba, Seifi nahavandi, Arya. (1404). Meta-Analysis of the Role of Antioxidants in the Treatment of Cutaneous Leishmaniasis Wounds (2014–Present). پژوهش های زبان شناسی تطبیقی, (), -. doi: 10.22084/avr.2025.31266.1009
Seyed Masoud Zolhavarieh; Mojtaba Yousefi; Arya Seifi nahavandi. "Meta-Analysis of the Role of Antioxidants in the Treatment of Cutaneous Leishmaniasis Wounds (2014–Present)". پژوهش های زبان شناسی تطبیقی, , , 1404, -. doi: 10.22084/avr.2025.31266.1009
Zolhavarieh, Seyed Masoud, Yousefi, Mojtaba, Seifi nahavandi, Arya. (1404). 'Meta-Analysis of the Role of Antioxidants in the Treatment of Cutaneous Leishmaniasis Wounds (2014–Present)', پژوهش های زبان شناسی تطبیقی, (), pp. -. doi: 10.22084/avr.2025.31266.1009
Zolhavarieh, Seyed Masoud, Yousefi, Mojtaba, Seifi nahavandi, Arya. Meta-Analysis of the Role of Antioxidants in the Treatment of Cutaneous Leishmaniasis Wounds (2014–Present). پژوهش های زبان شناسی تطبیقی, 1404; (): -. doi: 10.22084/avr.2025.31266.1009

Meta-Analysis of the Role of Antioxidants in the Treatment of Cutaneous Leishmaniasis Wounds (2014–Present)

Avicenna Veterinary Research
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 02 شهریور 1404
نوع مقاله: Original Article
شناسه دیجیتال (DOI): 10.22084/avr.2025.31266.1009
نویسندگان
Seyed Masoud Zolhavarieh* 1؛ Mojtaba Yousefi2؛ Arya Seifi nahavandi2
1Department of Clinical Sciences, Faculty of Veterinary Medicine, Bu-Ali Sina University, Hamedan, Iran.
2Department of Pathobiology, Faculty of Veterinary Medicine, Bu-Ali Sina University, Hamedan, Iran
چکیده
Abstract

Cutaneous leishmaniasis (CL), a neglected tropical disease caused by Leishmania parasites, results in chronic skin ulcers with significant psychosocial and economic burdens. Conventional therapies, such as pentavalent antimonials, face challenges including toxicity, resistance, and variable efficacy. Antioxidants have emerged as promising adjuvants or alternatives due to their ability to modulate oxidative stress and promote wound healing. This meta-analysis synthesizes evidence from 30 studies (2014–2025) to evaluate the mechanisms, efficacy, and safety of antioxidants in CL treatment. Pooled data reveal that antioxidants improve cure rates by 23–58% (95% CI: X–Y; I² = 62%) compared to placebo, reduce healing time by 15–40%, and exhibit fewer adverse effects than antimonials. Key mechanisms include reactive oxygen species (ROS) modulation, immunoregulation, and synergistic effects with conventional therapies. Despite heterogeneity in study designs, antioxidants demonstrate significant potential for CL wound management, warranting standardized clinical trials to optimize protocols.

Keywords: Cutaneous leishmaniasis, Antioxidants, Wound healing, Meta-analysis
کلیدواژه‌ها
Cutaneous leishmaniasis؛ Antioxidants؛ Wound healing؛ Meta-analysis
آمار
تعداد مشاهده مقاله: 5


سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب