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Protective Effects of Hydroalcoholic Extract of Nigella sativa on Enzymatic Activity and Kidney Histopathology in Mice Infected with Plasmodium berghei | ||
| Avicenna Veterinary Research | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 18 خرداد 1404 | ||
| نوع مقاله: Original Article | ||
| شناسه دیجیتال (DOI): 10.22084/avr.2025.30802.1003 | ||
| نویسندگان | ||
| Nilofar Saberi Niaki1؛ Amirhossein Esmaeili1؛ Taher Elmi* 2 | ||
| 1Department of Laboratory Science, Bab.C., Islamic Azad University, Babol, Iran. | ||
| 2Department of Parasitology and Mycology, School of Medicine, Arak University of Medical Sciences, Arak, Iran | ||
| چکیده | ||
| Nigella sativa is a medicinal plant traditionally used for the treatment of various diseases. The presence of essential fatty acids in Nigella sativa has contributed to its anticancer properties and its effectiveness in promoting skin health. This study aimed to evaluate the protective effect of the hydroalcoholic extract of Nigella sativa on enzymatic activity and renal histopathology in mice infected with Plasmodium berghei. A total of 35 adult male mice, were divided into 7 groups. The mice were infected with P. berghei to induce malaria. After confirmation of infection, the mice were treated with Nigella sativa extract for 4 consecutive days. At the end of the treatment period, blood samples were collected to measure serum levels of urea and creatinine. Additionally, kidney tissues were subjected to histopathological examination. The results demonstrated that the Nigella sativa extract at a dose of 400 mg/kg reduced serum levels of urea and creatinine compared to the negative control group (PBS). Histopathological assessment of the kidney tissues revealed no significant morphological differences between the control and treated groups. Furthermore, the lumen and epithelial lining of the renal convoluted tubules in the extract-treated group appeared similar to those in the negative control group, with no statistically significant changes observed (p > 0.05). Based on these findings, further long-term studies are recommended to investigate the potential of Nigella sativa extract in reducing elevated urea and creatinine levels in various pathological conditions. This extract may serve as an effective agent in managing renal dysfunction associated with different diseases | ||
| کلیدواژهها | ||
| Plasmodium berghei؛ malaria؛ Nigella sativa؛ renal histology | ||
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